Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate.

نویسندگان

  • Marylore Chenel
  • Anne Limosin
  • Sandrine Marchand
  • Joël Paquereau
  • Olivier Mimoz
  • William Couet
چکیده

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram (EEG) effect was combined with intracerebral glutamate determinations using microdialysis for rats receiving norfloxacin intravenously (150 mg/kg of body weight). The EEG effect (accompanied by tremors and seizures) was consistently observed without glutamate level modifications. Therefore, norfloxacin-inducted seizures are not triggered by intracerebral glutamate level enhancement.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 47 11  شماره 

صفحات  -

تاریخ انتشار 2003